Import Gsk — Buy in Bulk from Supplier in United States

Glycogen synthase kinase‑3 (GSK‑3) is a serine‑threonine protein kinase that phosphorylates a range of cellular substrates. The enzyme exists as two isoforms, GSK‑3α and GSK‑3β, each encoded by separate genes but sharing a conserved catalytic domain. In metabolic pathways it regulates glycogen synthase and ATP‑citrate lyase, while in the nervous system it phosphorylates tau protein, linking it to neurodegenerative research. The listing identifies the product simply as “GSK”, indicating that the supplier offers one or both isoforms for research use.

Recombinant GSK‑3 produced in E. coli typically displays a molecular weight of approximately 45 kDa and a specific activity around 1000 U mg⁻¹ when measured with a standard peptide substrate. Purity is commonly assessed by SDS‑PAGE, with a typical grade of ≥95 % of the target band. The enzyme is supplied in a lyophilised form, stored at - 20 °C, and reconstituted in a buffer containing 50 mM Tris‑HCl (pH 7.5), 10 % glycerol and 1 mM DTT, which is the standard formulation for maintaining activity. Stability data show that the lyophilised product retains >90 % activity after three months at - 20 °C, a typical shelf‑life for kinase preparations.

Researchers in biochemical, pharmaceutical and neuro‑biology fields use GSK‑3 for inhibitor screening, signalling pathway studies and antibody validation. The enzyme is sold to academic laboratories, contract research organisations and biotech companies that require a reliable source of active kinase. Creative Enzymes states that standard trade terms, including MOQ and shipping conditions, are provided upon request, and that the product complies with relevant safety and handling guidelines. Prospective buyers should request the certificate of analysis and any relevant batch records before confirming the purchase.

Creative Enzymes is located at 45‑16 Ramsey Road, Shirley, NY 11967, United States, and is listed as an imported supplier with a harbor trust tier. The company focuses on the production of recombinant enzymes for research applications, and its profile records a 0 % response rate with no average response time logged, indicating that communication may require follow‑up.

The catalogue includes a range of recombinant kinases, with GSK‑3 highlighted as a key product for signalling studies. No further details on production capacity, certifications or years of operation are disclosed, so interested buyers should verify these aspects directly with Creative Enzymes before proceeding.