Bilirubin Powder

Bilirubin powder is a tetrapyrrole bile pigment with the molecular formula C33H36N4O6, CAS number 635-65-4, occurring naturally as the final product of heme catabolism. Aritech Chemazone Pvt. Ltd. supplies this material as a micro powder with particle size controlled to 40-50 micrometres, with customisation available for specific pharmaceutical or diagnostic applications. The supplier states purity exceeding 99.99%, a figure that implies synthetic or highly purified semi-synthetic origin rather than direct isolation from biological sources, which typically yields 90-98% material with complex impurity profiles. The Z,Z-isomer (bilirubin IXalpha) predominates in the natural form and is the pharmaceutically relevant configuration; buyers should verify isomeric purity and the absence of photoisomerisation products (E,Z and E,E forms) that exhibit different solubility and metabolic behaviour. The fine particle size distribution of 40-50 micrometres enhances dissolution kinetics critical for diagnostic reagent formulation but requires careful handling to prevent electrostatic aggregation and respiratory exposure.

The material composition is specified as C33H36N4O6, corresponding to a molecular weight of 584.67 g/mol, with the characteristic yellow-orange colour in powder form transitioning to green upon oxidation. Bilirubin exists in two conformational forms: the intramolecularly hydrogen-bonded ridge-tile conformation (insoluble in water) and the open conformation (water-soluble, physiologically relevant for transport and conjugation). For pharmaceutical and diagnostic use, the unconjugated, water-insoluble form is typically supplied, with solubilisation achieved through alkaline pH, albumin binding, or organic solvents such as dimethyl sulfoxide or chloroform for analytical applications. The high stated purity suggests extensive recrystallisation and possibly preparative chromatography, processes that must be validated for residual solvent control per ICH Q3C guidelines. Stability concerns include photodegradation (particularly to photobilirubin and lumirubin isomers), oxidation, and pH-dependent aggregation; standard storage requires amber containers, inert atmosphere, and refrigeration at 2-8 degrees C with desiccant.

Primary applications encompass the manufacture of diagnostic kits for neonatal jaundice assessment (total and direct bilirubin assays), liver function test controls, and research into bilirubin neurotoxicity and antioxidant properties. Pharmaceutical interest centres on its potential therapeutic applications in metabolic syndrome, cardiovascular disease, and as an antioxidant, though regulatory approval varies. The buyer profile includes in vitro diagnostic (IVD) manufacturers, clinical chemistry control material producers, and academic research institutions. When sourcing from Aritech Chemazone, confirm whether the 99.99% purity figure represents area percent by HPLC-UV, weight percent by qNMR, or another methodology, as these yield non-interchangeable values. The Kurukshetra, Haryana location offers inland access via Delhi and Chandigarh for export through Delhi air freight or Mumbai/JNPT sea freight. Cold chain maintenance during transport is essential given thermal lability; negotiate temperature monitoring and deviation protocols for international shipment.

Aritech Chemazone Pvt. Ltd. operates from 890 Sector 7 Urban Estate in Kurukshetra, Haryana, India, a city located approximately 160 kilometres north of Delhi with connectivity through the Kurukshetra Junction railway station and proximity to National Highway 44. The supplier holds a harbor trust tier on the platform, with a 0.00% response rate and zero recorded average response hours, indicating no platform-mediated buyer engagement to date. The address in Sector 7 Urban Estate suggests an industrial or commercial zone rather than a standalone manufacturing facility, though this cannot be confirmed from available data alone. No employee count, annual revenue, year of establishment, or client references are provided in the source material.

The company positions itself as a supplier of bilirubin powder for pharmaceutical manufacturing, diagnostic reagent production, and biochemical research, with emphasis on fine chemical and specialised material distribution. The listing contains no GMP certification, ISO accreditation, or manufacturing licence numbers; the high purity claim of 99.99% requires independent verification through batch testing or supplier audit. Buyers should request the company's Drug Manufacturing Licence (Form 28) if claiming pharmaceutical manufacture, or their wholesale drug licence (Form 20B/21B) for trading operations in India. Given the limited platform verification, conduct due diligence through the Ministry of Corporate Affairs (MCA) portal for company registration status, and consider engaging a local representative for pre-shipment inspection.