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5-Amino-2,4,6-triiodisophthaloyl acid dichloride is the diacid chloride derivative of 5-amino-2,4,6-triiodoisophthalic acid, a reactive intermediate distinguished by its two acyl chloride functional groups that enable direct amidation without additional carboxylic acid activation. With molecular weight 395.25 g/mol and purity exceeding 98% according to Shouguang Kuibao Chemical Technology Co., Ltd's specification, this white crystalline powder serves as a more reactive alternative to the free acid in convergent synthesis of nonionic X-ray contrast agents. The compound's reactivity profile makes it particularly suited for coupling with polyhydroxylated amines under controlled conditions.
The acid chloride groups exhibit characteristic reactivity with nucleophiles, requiring handling under anhydrous conditions to prevent hydrolysis back to the parent diacid. Shouguang Kuibao Chemical Technology Co., Ltd supplies this material from Shouguang, Shandong Province, within the Bohai Chemical Industrial Park, a region with established fine chemical manufacturing infrastructure. The white crystalline appearance indicates proper handling and storage; discoloration to yellow or brown suggests decomposition or inadequate moisture exclusion during production or storage.
Primary applications include pharmaceutical manufacturing of iodinated contrast media, particularly where direct amidation routes reduce overall step count and improve process economics. The compound also finds use in research laboratories developing novel imaging agents and in specialty chemical synthesis where activated carboxylic acid derivatives are required. Buyers should confirm with Shouguang Kuibao Chemical Technology Co., Ltd the specific batch size availability, lead time from order confirmation, and whether technical support for handling and reaction optimization is provided, as the listing does not specify these operational details.
| Chemical Name | 5-Amino-2,4,6-triiodoisophthaloyl dichloride |
| Molecular Weight | 395.25 g/mol (supplier-stated) |
| Purity | Exceeds 98% (supplier-stated) |
| Appearance | White crystalline powder (supplier-stated) |
| CAS Number | Typical CAS 37441-29-5 (standard for this acid chloride derivative) |
| Chemical Formula | Typical C8H2I3Cl2NO2 (standard diacid chloride structure) |
| Reactivity | Typical: moisture-sensitive acyl chloride, hydrolyzes to parent diacid on exposure to water (standard for aromatic acid chlorides) |
| Solubility | Typical: soluble in dry organic solvents such as dichloromethane, THF, and toluene; reacts with alcohols, amines, and water (standard for acid chlorides) |
| Storage Conditions | Typical: -20°C to +4°C under inert gas (nitrogen or argon), tightly sealed, des有成 desiccant (standard for moisture-sensitive acyl chlorides) |
| Primary Application | Pharmaceutical intermediate for nonionic iodinated contrast agents via direct amidation |
Shouguang Kuibao Chemical Technology Co., Ltd is located at No.8, Bohai Road, Bohai Chemical Industrial Park, Shouguang 262714, Shandong Province, China. The supplier holds an imported tier designation and harbor trust tier on the platform, though their response rate is recorded at 0.00% with zero hours average response time, indicating no active quotation engagement through this particular channel. The company's positioning within a dedicated chemical industrial park suggests access to shared infrastructure for chemical processing, waste management, and environmental compliance typical of such zoned developments in China.
The available profile does not disclose founding date, employee numbers, annual production capacity, revenue figures, specific quality certifications, or named clientele. No GMP compliance, ISO registration, or regulatory filing information appears in the source data. Buyers must independently verify Shouguang Kuibao Chemical Technology Co., Ltd's manufacturing scope license, environmental compliance records, and whether their facilities are subject to or have passed audits by pharmaceutical customers or regulatory authorities. The absence of response history means direct outreach, potentially supplemented by site visit to their Shouguang address, is advisable before committing to supply agreements.
| Business Type | Supplier |
| Year Established | Recently Joined |
| Employees | Contact Supplier |
| Annual Revenue | Contact Supplier |
| Main Products | View Products Tab |
| Major Markets | Global |
| Response Time | <4h |
| Response Rate | New Supplier |
Before committing to Shouguang Kuibao Chemical Technology Co., Ltd, verify their business registration, chemical production license, and environmental compliance status through Shandong provincial authorities. Request a current certificate of analysis from an actual production lot with all tests performed, not a template or historical batch. Validate their analytical capabilities by asking for raw data from HPLC, IR, and assay methods. Given the zero response rate on this platform, consider engaging through their direct contact at the Bohai Road address or through chemical industry networks in Shouguang. Verify that their facility has appropriate containment for iodinated compound handling, as iodine volatility and occupational exposure require specific engineering controls.
Shipping from Shouguang typically routes through Qingdao or Tianjin port for international export. Confirm the exact port, Incoterms (FOB, CIF, or other), and whether the acid chloride classification triggers hazardous material shipping requirements under IATA or IMO regulations. Acid chlorides are often classified as corrosive (Class 8) and may require specific packaging, labeling, and documentation. Payment terms should be negotiated based on relationship history; for initial orders, consider documentary credit or escrow arrangements. The listing mentions FOB and CIF without specificity, so request quotation with precise Incoterms 2020 definitions, including point of delivery and cost allocation between seller and buyer for freight, insurance, and export formalities.
Upon receipt, inspect packaging integrity for moisture ingress indicators, and verify seal condition before accepting delivery. Store immediately at recommended temperature under inert atmosphere; do not allow material to warm to ambient conditions for extended periods. Perform incoming testing: appearance (white crystalline, no discoloration), identity by FT-IR with acid chloride carbonyl confirmation, assay by titration, and water content by Karl Fischer. Retain samples under proper conditions for dispute resolution or regulatory reference. Establish a requalification protocol: if storage exceeds recommended duration or temperature excursions occur, retest for hydrolysis before use. For GMP applications, maintain vendor qualification files including change control notifications, deviation reports, and annual quality reviews. Given the reactive nature of this intermediate, consider contractual agreements for batch reservation and just-in-time delivery to minimize on-site storage duration and associated stability risks.
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