从China供应商批发进口3-[(Dimethylamino)Methyl]-1,2,3,9-Tetrahydro-9-M — FOB条款

3-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one HCl (CAS 99614-70-7) is a carbazole-derived pharmaceutical intermediate supplied by Qingdao Henley Co., Ltd. from their location in Qingdao, China. The compound features a dimethylaminomethyl substituent at the 3-position of a tetrahydrocarbazolone core, with the hydrochloride salt form conferring enhanced water solubility for formulation work. The molecular structure places it within the class of tricyclic indole alkaloid analogues used in serotonin receptor ligand synthesis.

This material is typically manufactured via reductive amination or Mannich-type condensation on the parent ketone, with subsequent salt formation. Standard purity benchmarks for such intermediates range from 98.0% to 99.5% by HPLC area, with typical residual solvent levels controlled per ICH Q3C guidance (methanol <3000 ppm, toluene <890 ppm, dichloromethane <600 ppm). The free base has limited stability; the HCl salt form, as offered here, provides the standard commercial format for long-term storage and reproducible dosing in scale-up operations. Typical packaging for pharmaceutical intermediates of this class is 25 kg net weight per fibre drum with double polyethylene liner, though the exact configuration from this supplier should be confirmed.

Primary applications include use as a building block in the synthesis of antiemetic agents, specifically ondansetron and related 5-HT3 antagonists, where the dimethylaminomethyl handle enables further N-alkylation or quaternisation. Research laboratories and generic API manufacturers represent the core buyer segments. Importers should note that this CAS number appears on EU REACH and US EPA TSCA inventories, though registration status and permitted uses vary by jurisdiction. Qingdao Henley lists this as a bulk supply item; buyers must confirm the specific batch COA parameters, retest date, and whether DMF-type documentation is available for pharmaceutical applications.

Qingdao Henley Co., Ltd. operates from office suite 6C04 on the seventh floor of Xiangdao Plaza at 77 Xianggan Road, Qingdao 266071, in Shandong Province, China. The supplier carries an 'imported' tier classification within the platform system, with a 'harbor' trust designation. Their response metrics show 0.00% response rate and zero average response hours at the time of listing, which indicates no historical response data is available through the platform. Buyers should treat direct outreach as the primary channel for engagement and verification.

The company profile does not disclose manufacturing site details, GMP certification status, ISO accreditation, or R&D capabilities. No information is provided on annual output, number of chemists, quality control instrumentation (e.g., NMR, LCMS, GC-MS availability), or whether the firm operates as a manufacturer, trader, or hybrid. The listing describes bulk supply availability without stating minimum order quantities, price bands, or standard lead times. Importers should request a supplier questionnaire, audit the quality management system, and verify whether Qingdao Henley holds a valid API registration or DMF with any regulatory authority before committing to pharmaceutical-grade purchases.