Import Berberine Hcl/ Berberine Sulfate — Buy in wholesale FOB from Supplier in China

Berberine HCl (C20H18ClNO4) and Berberine Sulfate ((C20H18NO4)2·SO4) are isoquinoline alkaloids extracted from the rhizomes of Coptis chinensis and the bark of Phellodendron chinense, plants native to central and southwestern China. Chengdu Chenlv Herb Co. Ltd., based in Sichuan Province, supplies these compounds in bulk for pharmaceutical and nutraceutical manufacturing. The hydrochloride salt and sulfate salt forms differ in molecular weight, solubility profile, and stability in tablet matrices, with HCl being the more common pharmaceutical grade for oral dosage forms. The supplier's location in Chengdu places it near major cultivation zones for both source botanicals.

The raw material specification hinges on botanical provenance: Coptis chinensis rhizome contains 5-8% berberine by dry weight, while Phellodendron chinense bark yields 3-4%, requiring extraction and purification to achieve pharmaceutical grades. Typical purity thresholds for API-grade berberine salts range from 97% to 99% measured by HPLC against reference standards such as USP or EP monographs. The extraction process involves acidified water or ethanol extraction, followed by crystallisation, with residual solvent limits governed by ICH Q3C guidelines. Standard packaging for bulk alkaloid APIs is 25 kg net weight in double-lined polyethylene bags within fibre drums, with nitrogen flushing to prevent oxidative degradation of the phenolic structure.

Primary buyers are contract manufacturers of dietary supplements, functional food producers, and pharmaceutical companies formulating antidiabetic, antimicrobial, or cardiovascular support products. The alkaloid's poor oral bioavailability drives demand for enhanced formulations, including nanoparticle delivery or complexation with absorption enhancers. Sourcing considerations include verification of raw plant species identity, as adulteration with Berberis species or synthetic analogues is a documented risk in global trade. Buyers should request batch-specific Certificate of Analysis data covering heavy metals, aflatoxins, and microbial limits, plus botanical origin documentation to satisfy customs and regulatory requirements in destination markets.

Chengdu Chenlv Herb Co. Ltd. operates from No.125 Yanjin Road in Pujiang County, Chengdu, Sichuan Province, China (postal code 611633). The supplier holds a harbor trust tier designation on the platform, with a recorded response rate of 0.00 and zero average response hours, indicating no response history is currently logged. The company's product focus spans botanical extracts and alkaloid APIs for B2B pharmaceutical and nutraceutical markets, with berberine salts positioned as a core export offering.

The available profile does not disclose manufacturing certifications, annual output volumes, employee count, or specific client references. Buyers should independently verify GMP compliance, API registration status, and audit trails for botanical sourcing. The Sichuan location offers proximity to both raw material cultivation regions and Chengdu Shuangliu International Airport for air freight of time-sensitive or high-value shipments. Direct engagement is essential to confirm quality management systems, batch testing protocols, and regulatory documentation capabilities.